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Obesity is known to be tied to infertility in women , and a new study intimate a potential reason why : the brain ’s pituitary gland may be sensitive to the increased insulin levels that occur with obesity , and in turn , may vitiate fertility .
The study , convey in mice , usher that high levels of insulin , a endocrine that help control blood sugar , act on the pituitary gland , which is need in regulating ovulation . grand levels of insulin , a side burden ofobesity , prompt thepituitary glandto pump out orotund sum of hormones that disrupt ovulation .
This burden of insulin on the pituitary secretory organ is dissimilar from its essence on other parts of the body , the researchers say . In obese people , cells in the liver and sinew can stop respond to insulin , a state known asinsulin resistor , which is link to Type 2 diabetes . The new study suggests that not all cellphone in the consistency become insulin insubordinate .
" What we offer is a fundamentally Modern fashion model show that different tissues respond to obesity other than , and that while cell in the liver and musculus do become insulin resistant , cell in the pituitary rest sensitive to insulin , " enunciate subject area investigator Andrew Wolfe of Johns Hopkins Children ’s Center in Baltimore .
More research is needed to see whether the finding confine unfeigned for humans , the researchers say .
Insulin in the psyche
The researchers focused on pituitary cells call gonadotrophs which bring out luteinizing internal secretion , vital for ovulation andfertility .
They mastermind computer mouse with missing insulin sensory receptor in their pituitary glands and liken them to mice with entire insulin sensory receptor ( cellular telephone without insulin receptors can not receive or react to the insulin signal ) .
After three calendar month on a high - fat diet , the weighty mice with integral insulin receptors developed all the classic symptom of polycystic ovary syndrome , a unwashed cause of infertility in fair sex . Some of the black eye ’s symptom include irregular reproductive cycles and few ovulations .
The black eye with missing insulin receptors , however , maintained near - normal degree of luteinizing hormone , regular cycle per second and normal ovulation , despite their corpulency .
shock on gestation
To set whether these hormonal differences would channel over into real difference in fertility , the researchers permit the mice to checkmate . Thepregnancyresults mirror the hormonal determination .
weighty mice with missing pituitary insulin sensory receptor had most - normal pregnancy rate , with five times more successful pregnancies than rotund mouse whose pituitary insulin receptors were intact .
The study will be publish online Sept. 8 in the journal Cell Metabolism .
